You have to increase the pressure somewhat to compensate for the line diameter decrease and the resultant loss of pressure. The easiest way to do that accurately is to build a tee with a pressure gauge on it and put it on the nozzle end. Then, when you get the desired nozzle pressure, mark the pump discharge pressure on the pressure gauge with a sharpie so you know what yu need to be pumping. You can also use this technique to ensure pressure consistency from bay to bay. It takes a few extra hundred PSI at the pump with 1/4 hose but my setup with cat 5cp2120s and 3HP motors seems to work fine. I do use a lower end of the pressure sprayer at a 2506 nozzle and 1000 psi at the tip. The changeover time seems noticeably better when you're waiting for it, but in reality it's probably somewhere between 5-20 seconds, depending on the distance of the bay from the equipment room.