I suspect you're going to get a lot of opinions on this question!
I've tried half a dozen, I like the paraplate guns, they fit my hand just right, and I like the grip/spray angle.
Regarding the "fatigue" part of your question, I do notice a lot of women dont pull the trigger, and definitely dont wash as long as men do. Was discussing that with my wife on veterans day, and we discussed it with the Suttner rep at
Kleen Rite's expo a few weeks ago. He handed me their "easy pull" spray gun. Have to admit I liked it, I'm going to try one when I place my next order. It was almost effortless to pull the trigger and hold it. Interested to see how it feels in the bay under pressure.
http://https://www.kleen-ritecorp.com/p-2276-suttner-202300615-easy-pull-spray-gun-weep.aspx
I've long wondered whether I need a "ladies bay" with lower pressure, etc. Kind of the opposite of the "super bay" some of you guys have had over the years.